Infliximab Treatment of Refractory Cardiac Sarcoidosis

Autor: Majid Asawaeer, MD, Benjamin Widener, MD, Varda Singhal, MBBS, Matthew J. DeVries, MD, Debra J. Romberger, MD, Alan R. Erickson, MD, Yiannis S. Chatzizisis, MD, PhD
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: JACC: Case Reports, Vol 2, Iss 10, Pp 1553-1557 (2020)
Druh dokumentu: article
ISSN: 2666-0849
DOI: 10.1016/j.jaccas.2020.06.041
Popis: Treatment of cardiac sarcoidosis is challenging, as the disease can be refractory to traditional treatment with steroids. Infliximab, a tumor necrosis factor-α inhibitor, has been reportedly used in cardiac sarcoidosis, but published evidence is limited. The potential cardiotoxicity of infliximab and the Food and Drug Administration black-box warning for patients with heart failure have hindered the use of this agent in cardiac sarcoidosis. Here, we report a case of refractory cardiac sarcoidosis successfully treated with infliximab and discuss the important role of fluorine-18–fluorodeoxyglucose positron emission tomography in prognostication and guidance of therapy. (Level of Difficulty: Intermediate.)
Databáze: Directory of Open Access Journals