6,7-Dihydroxy-5,8-dimethoxy-2H-chromen-2-one
Autor: | Olga I. Adaeva, Dmitry V. Demchuk, Victor V. Semenov |
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Jazyk: | angličtina |
Rok vydání: | 2023 |
Předmět: | |
Zdroj: | Molbank, Vol 2023, Iss 3, p M1702 (2023) |
Druh dokumentu: | article |
ISSN: | 1422-8599 |
DOI: | 10.3390/M1702 |
Popis: | This article presents a novel approach for synthesizing a new 5,8-dimethoxy derivative of esculetin via the selective cleavage of the methylene bridge in sabandin—naturally occurring and easily synthetically accessible methoxylated coumarin. A high selectivity is achieved by using acetoxylation of methylenedioxy group with lead tetraacetate. Natural coumarin sabandin as a starting compound was prepared in a few simple steps from 5-allyl-4,7-dimethoxybenzo[d][1,3]dioxole (apiol), which is readily available from parsley and dill seed extracts. The developed method enables an efficient and straightforward synthesis of a new derivative of esculetin with potential medicinal and therapeutic applications. |
Databáze: | Directory of Open Access Journals |
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