| Autor: |
Rhodora C. Calizo, Smiti Bhattacharya, J. G. Coen van Hasselt, Chengguo Wei, Jenny S. Wong, Robert J. Wiener, Xuhua Ge, Nicholas J. Wong, Jia-Jye Lee, Christina M. Cuttitta, Gomathi Jayaraman, Vivienne H. Au, William Janssen, Tong Liu, Hong Li, Fadi Salem, Edgar A. Jaimes, Barbara Murphy, Kirk N. Campbell, Evren U. Azeloglu |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-019-09936-x |
| Popis: |
Kinase inhibitors used in chemotherapy are known for their adverse effects on kidney physiology. Here, Calizo et al. show that dasatinib is associated with a higher risk of glomerular toxicity compared to other kinase inhibitors, due to deleterious effects on cytoskeletal biomechanics in podocytes. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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