Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity

Autor:	T. N. Sharapova, E. A. Romanova, L. P. Sashchenko, D. V. Yashin
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Immunologic diseases. Allergy RC581-607
Zdroj:	Journal of Immunology Research, Vol 2018 (2018)
Druh dokumentu:	article
ISSN:	2314-8861 2314-7156
DOI:	10.1155/2018/4501273
Popis:	We have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity. These cells can induce lysis of HLA-negative tumor cell lines. The Hsp70 stress molecule on the surface of the tumor cells is used as a recognition target, while the Tag7 protein on the lymphocyte membrane acts as a receptor for Hsp70. We have also demonstrated that this subpopulation of the CD4+CD25+ cells is CD127 positive and hence is not the Treg cells. Our data suggest that this subpopulation of cells is identical to the CD4+CD25+ lymphocytes, which are activated in the leukocyte pool by the IL-2 cytokine.
Databáze:	Directory of Open Access Journals
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