Sarcopenia Is Independently Associated with the Degree of Liver Fibrosis in Patients with Type 2 Diabetes Mellitus

Autor: Min Je Sung, Tae Seop Lim, Mi Young Jeon, Hye Won Lee, Beom Kyung Kim, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Jun Yong Park, Seung Up Kim
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Gut and Liver, Vol 14, Iss 5, Pp 626-635 (2020)
Druh dokumentu: article
ISSN: 1976-2283
DOI: 10.5009/gnl19126
Popis: Background/Aims: Sarcopenia is associated with liver fibrosis in patients with nonalcoholic fatty liver disease and chronic hepatitis B. We investigated the association between sarcopenia and hepatic fibrotic burden in patients with type 2 diabetes mellitus (T2DM). Methods: Patients with T2DM who had received a comprehensive medical health checkup were recruited. Muscle mass was assessed using computed tomography. Fibrotic burden was assessed using the fibrosis-4 index (FIB-4). The study population was divided by quartile stratification of the lumbar skeletal muscle index (LSMI). Results: Among 309 patients with T2DM, 75 (24.3%) had sarcopenia. These patients were significantly older and had higher FIB-4, whereas they had significantly lower body mass index (BMI) and LSMI than patients without sarcopenia (all p
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