| Autor: |
Jihye Baek, Jong-Hwa Kim, YoHan Nam, Go-Eun Kim, Kyungheon Ryu, Soonok Sa, Jung-Sook Han, Wonyong Kim |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 108, Iss , Pp 105721- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2023.105721 |
| Popis: |
d-allulose, a fructose isomer with almost zero calories, has been widely used as a food ingredient that is generally recognized as safe. In recent studies, d-allulose has been shown to alleviate some diseases via restoration of the intestinal barrier. To better understand the role of d-allulose in intestinal epithelial barrier function, we conducted experiments to demonstrate its effects. Our results demonstrated that d-allulose increased transepithelial electrical resistance and decreased intestinal barrier function–associated permeability toward 4 kDa FITC–dextran flux in the damaged intestinal epithelial barrier. It also repaired the disruption pattern of tight junction proteins (ZO-1, occludin, and claudin-1) and inhibited the inflammatory response by inhibiting the TLR4/MyD88/NF-κB pathway. Overall, these findings suggest that d-allulose has the potential to be a beneficial food supplement for improving intestinal epithelial barrier dysfunction. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Full Text from ScienceDirect