Treatment outcomes of mucosal melanoma of the head and neck: Analysis of 190 cases from a single institution

Autor: Shu‐Wei Chen, Meng‐Hua Li, Jian‐Liang Liu, Jing‐Tao Chen, Jia Wang, Hui Li, Xi‐Yuan Li, Ying Zhang, Ming Song, Jia‐Xuan Lu, Wen‐Kuan Chen
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Laryngoscope Investigative Otolaryngology, Vol 8, Iss 3, Pp 686-692 (2023)
Druh dokumentu: article
ISSN: 2378-8038
DOI: 10.1002/lio2.1072
Popis: Abstract Objectives To analyze the treatment outcomes and prognostic factors of mucosal melanoma of the head and neck (MMHN) from a single institution. Methods From December 1989 to November 2018, 190 patients diagnosed with MMHN were included. Survival analysis was performed using the Kaplan–Meier method for univariate analysis with a log‐rank test for significance and Cox regression for multivariate analysis. Results With a median follow‐up time of 43.5 months, 126 (68.5%) patients died. The median DSS was 35 months. The 3‐ and 5‐year disease‐specific survival (DSS) rates were 48.1% and 33.7%, respectively. The median overall survival (OS) was 34 months. The 3‐ and 5‐year OS rates were 47.0% and 32.9%, respectively. In univariate analysis, the T3 stage, received surgery, R0 resection, and combined therapy (surgery+biotherapy/biochemotherapy) were significantly associated with better survival. Multivariable Cox regression analysis revealed that the T4 stage (HR = 1.692; 95% CI, 1.175–2.438; p = .005) and the N1 stage (HR = 1.600; 95% CI, 1.023–2.504; p = .039) were strong prognostic factors for poor survival, and that combined therapy (surgery+biotherapy/biochemotherapy) was a strong prognostic factor for better survival outcome (HR = 0.563; 95% CI, 0.354–0.896; p = .015). Conclusion The prognosis of MMHN remains poor. Systemic treatment is warranted to reduce MMHN progression. Surgery combined with biotherapy may improve survival.
Databáze: Directory of Open Access Journals
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