| Autor: |
Sabiha Abdul Aziz Shaikh, Ceena Denny E, Reshma Kumarchandra, Srikant Natarajan, Johan Sunny, Nandita Shenoy, Nandita K. P |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Oral Health, Vol 5 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2673-4842 |
| DOI: |
10.3389/froh.2024.1375162 |
| Popis: |
IntroductionTumor necrosis factor α (TNF-α) is known to be associated with chronic inflammation, and its expression has been shown to increase in advanced cancers. Chronic inflammation is a characteristic feature of oral submucous fibrosis (OSMF), which is a potentially malignant disorder (PMD). Squamous cell carcinoma (SCC) is associated with considerable mortality and morbidity and an early detection or monitoring would greatly help in achieving an effective cure. TNF-α was thus evaluated for use as a biomarker in the present study according to the stage of OSMF and histological grade of SCC in the oral cavity and oropharynx.MethodsThis study included 45 patients divided into 3 groups—OSMF group, SCC group and control group—each comprising 15 participants. Saliva samples were collected from each patient, and salivary TNF-α levels were estimated using an ELISA kit.ResultsStatistical analysis revealed no significant differences in TNF-α levels among the OSMF, SCC and control groups; however, there was an increase in the salivary TNF-α level in patients with stage 3 disease according to the clinical stage of OSMF, for which the p value was 0.027.DiscussionAn increase in the TNF-α concentration with increasing clinical stage suggested a role for TNF-α in the spread of OSMF involvement in anatomical structures of the oral cavity and oropharynx. No significant difference in salivary TNF-α levels was noted among the OSMF, SCC and control groups.ConclusionThe study showed a positive correlation of TNF-α with increasing stages of OSMF but was not a reliable biomarker in the categorization of the same. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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