Corneal confocal microscopy demonstrates minimal evidence of distal neuropathy in children with celiac disease.

Autor: Hoda Gad, Saras Saraswathi, Bara Al-Jarrah, Ioannis N Petropoulos, Georgios Ponirakis, Adnan Khan, Parul Singh, Souhaila Al Khodor, Mamoun Elawad, Wesam Almasri, Hatim Abdelrahman, Khalid Hussain, Mohamed A Hendaus, Fatma Al-Mudahka, Khaled Abouhazima, Paraic McGrogan, Rayaz A Malik, Anthony K Akobeng
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: PLoS ONE, Vol 15, Iss 9, p e0238859 (2020)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0238859
Popis: ObjectivesThe aim of this study was to utilise corneal confocal microscopy to quantify corneal nerve morphology and establish the presence of sub-clinical small fibre damage and peripheral neuropathy in children with celiac disease.MethodsThis is a cross-sectional cohort study of twenty children with celiac disease and 20 healthy controls who underwent clinical and laboratory assessments and corneal confocal microscopy. Corneal nerve fiber density (no.mm2), corneal nerve branch density (no.mm2), corneal nerve fiber length (mm.mm2), corneal nerve fiber tortuosity and inferior whorl length (mm.mm2) were quantified manually.ResultsCorneal nerve fiber density (34.7±8.6 vs. 32.9±8.6; P = 0.5), corneal nerve branch density (47.2±24.5 vs. 47.3±20.0; P = 0.1) and corneal nerve fiber length (20.0±5.1 vs. 19.5±4.5; P = 0.8) did not differ between children with celiac disease and healthy controls. Corneal nerve fiber tortuosity (11.4±1.9 vs 13.5±3.0; P = 0.01) was significantly lower and inferior whorl length (20.0±5.5 vs 23.0±3.8; P = 0.06) showed a non-significant reduction in children with celiac disease compared to healthy controls. Inferior whorl length correlated significantly with corneal nerve fiber density (P = 0.005), corneal nerve branch density (P = 0.04), and corneal nerve fiber length (P = 0.002).ConclusionCorneal confocal microscopy demonstrates minimal evidence of neuropathy in children with celiac disease.
Databáze: Directory of Open Access Journals
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