Investigation of Mir-210 Expression in Breast Cancer Patients
| Autor: | Omolbanin Amjadi, Fatemeh Samadi, Reza Alizadeh-Navaei, Reza Valadan, Ehsan Zaboli, Najmeh Ahangar, Elahe Mahmoodi, Akbar Hedayatizadeh-Omran |
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| Jazyk: | English<br />Persian |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Mazandaran University of Medical Sciences, Vol 33, Iss 227, Pp 118-125 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1735-9260 1735-9279 |
| Popis: | Background and purpose: Breast cancer is one of the most common cancers among women. Abnormal expression of microRNAs is associated with cancer. Therefore, this study aimed to evaluate the expression of miRNA-210 in the serum of breast cancer patients. Materials and methods: The studied population included 49 breast cancer patients and 55 healthy individuals, and the samples were evaluated using Real Time PCR. Results: The data analysis of this study revealed that the expression level of miR-210 in the blood of breast cancer patients is significantly higher compared to the blood of healthy people. Also, there is a negative correlation between the age of breast cancer patients and the expression of miR-210 (r=-0.309, P=0.031) and a significant positive correlation between the increase in the expression of mir-210 and the expression of the Ki-67 marker (r=0.412, P = 0.004). |
| Databáze: | Directory of Open Access Journals |
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