Ebola Hemorrhagic Fever Associated with Novel Virus Strain, Uganda, 2007–2008
| Autor: | Joseph F. Wamala, Luswa Lukwago, Mugagga Malimbo, Patrick Nguku, Zabulon Yoti, Monica Musenero, Jackson Amone, William Mbabazi, Miriam Nanyunja, Sam Zaramba, Alex Opio, Julius J. Lutwama, Ambrose O. Talisuna, Sam I. Okware |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Emerging Infectious Diseases, Vol 16, Iss 7, Pp 1087-1092 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1080-6040 1080-6059 46729887 |
| DOI: | 10.3201/eid1607.091525 |
| Popis: | During August 2007–February 2008, the novel Bundibugyo ebolavirus species was identified during an outbreak of Ebola viral hemorrhagic fever in Bundibugyo district, western Uganda. To characterize the outbreak as a requisite for determining response, we instituted a case-series investigation. We identified 192 suspected cases, of which 42 (22%) were laboratory positive for the novel species; 74 (38%) were probable, and 77 (40%) were negative. Laboratory confirmation lagged behind outbreak verification by 3 months. Bundibugyo ebolavirus was less fatal (case-fatality rate 34%) than Ebola viruses that had caused previous outbreaks in the region, and most transmission was associated with handling of dead persons without appropriate protection (adjusted odds ratio 3.83, 95% confidence interval 1.78–8.23). Our study highlights the need for maintaining a high index of suspicion for viral hemorrhagic fevers among healthcare workers, building local capacity for laboratory confirmation of viral hemorrhagic fevers, and institutionalizing standard precautions. |
| Databáze: | Directory of Open Access Journals |
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