Design, Synthesis, and Characterization of an Amphiphilic Lipoic Acid-Based Ru(III) Complex as a Versatile Tool for the Functionalization of Different Nanosystems

Autor:	Claudia Riccardi, Chiara Platella, Domenica Musumeci, Daniela Montesarchio
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Ru(III) complexes amphiphilic compounds nucleolipids lipoic acid chemical synthesis half-life time Organic chemistry QD241-441
Zdroj:	Molecules, Vol 28, Iss 15, p 5775 (2023)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules28155775
Popis:	Ru-based chemotherapy is emerging as an effective alternative to the well-established Pt-based one, typically associated with high toxicity. In this context, our recent efforts were devoted to the preparation of nucleolipid-based Ru(III) complexes able to form, under physiological conditions, supramolecular aggregates which can efficiently prevent metal deactivation and convey Ru(III) inside the cells where it exerts its activity. Within an interdisciplinary program for the development of multifunctional nanoparticles for theranostic applications, we here report the design, synthesis, and characterization of a novel functionalized Ru(III) salt, carrying a lipoic acid moiety in the nucleolipid-based scaffold to allow its incorporation onto metal-based nanoparticles.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8205f699b01c4250befdb78eb3540f3a Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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