Synthesis and Cytotoxic Activity of New Vindoline Derivatives Coupled to Natural and Synthetic Pharmacophores
| Autor: | András Keglevich, Leonetta Dányi, Alexandra Rieder, Dorottya Horváth, Áron Szigetvári, Miklós Dékány, Csaba Szántay, Ahmed Dhahir Latif, Attila Hunyadi, István Zupkó, Péter Keglevich, László Hazai |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Molecules, Vol 25, Iss 4, p 1010 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1420-3049 25041010 |
| DOI: | 10.3390/molecules25041010 |
| Popis: | New Vinca alkaloid derivatives were synthesized to improve the biological activity of the natural alkaloid vindoline. To this end, experiments were performed to link vindoline with various structural units, such as amino acids, a 1,2,3-triazole derivative, morpholine, piperazine and N-methylpiperazine. The structure of the new compounds was characterized by NMR spectroscopy and mass spectrometry (MS). Several compounds exhibited in vitro antiproliferative activity against human gynecological cancer cell lines with IC50 values in the low micromolar concentration range. |
| Databáze: | Directory of Open Access Journals |
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