Intratumoral immunosuppression profiles in 11q‐deleted neuroblastomas provide new potential therapeutic targets

Autor: Esther Coronado, Yania Yañez, Enrique Vidal, Luis Rubio, Francisco Vera‐Sempere, Antonio José Cañada‐Martínez, Joaquín Panadero, Adela Cañete, Ruth Ladenstein, Victoria Castel, Jaime Font de Mora
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Molecular Oncology, Vol 15, Iss 2, Pp 364-380 (2021)
Druh dokumentu: article
ISSN: 1878-0261
1574-7891
DOI: 10.1002/1878-0261.12868
Popis: High‐risk neuroblastoma (NB) patients with 11q deletion frequently undergo late but consecutive relapse cycles with fatal outcome. To date, no actionable targets to improve current multimodal treatment have been identified. We analyzed immune microenvironment and genetic profiles of high‐risk NB correlating with 11q immune status. We show in two independent cohorts that 11q‐deleted NB exhibits various immune inhibitory mechanisms, including increased CD4+ resting T cells and M2 macrophages, higher expression of programmed death‐ligand 1, interleukin‐10, transforming growth factor‐beta‐1, and indoleamine 2,3‐dioxygenase 1 (P
Databáze: Directory of Open Access Journals
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