Tk-deleted pseudorabies virus retains high pathogenicity in rats

Autor: Zhang Lirong, Ruan Keyue, Sang Guoju, Xu Zhaoyang, Tong Wu, Yu Hai, Shan Tongling, Gao Fei, Li Liwei, Kong Ning, Tong Guangzhi, Zheng Hao
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Veterinary Research, Vol 65, Iss 4, Pp 401-405 (2021)
Druh dokumentu: article
ISSN: 2450-8608
DOI: 10.2478/jvetres-2021-0056
Popis: The pseudorabies virus (PRV) gene encoding thymidine kinase (tk) is an important virulence-associated factor. Attenuation of PRV in susceptible animals is a frequent result of tk deletion. The aim of the study was to assess the pathogenicity of tk-deleted PRV in rats.
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