| Autor: |
Marcelo Antonini, Silvio Martinelli, Ana Paula Marques Fernandes Yoshizumi, Sidney Antonio Lagrosa Garcia, Umberto Gazi Lippi |
| Jazyk: |
English<br />Portuguese |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
Einstein (São Paulo), Vol 5, Iss 1, Pp 51-55 (2007) |
| Druh dokumentu: |
article |
| ISSN: |
1679-4508 |
| Popis: |
Objective: To prepare a chart for normal values of thyroid-stimulatinghormone (TSH) and free thyroxin (free T4) and to verify the correlationbetween them, in pregnant women. Methods: A prospective crosssectionalstudy was performed on 850 pregnant women of thePrenatal Outpatient Clinic of the Hospital do Servidor Público Estadual– Francisco Morato de Oliveira (HSPE – FMO), from August 2003 toAugust 2005. Serum TSH and free T4 levels were determined usingmicroparticle enzyme immunoassay (MEIA). Maternal age ranged from18 to 47 years, mean of 32.5 ± 6.9 years. Mean gestational age was19.1 ± 8.5 weeks. With linear regression analysis, the 50th and 97.5thpercentiles for TSH and the 2.5th, 50th and 97.5th percentiles for free T4,at weeks 6 to 42 were calculated. The possible correlation betweenthese two indicators was analyzed. Results: Mean TSH and free T4values were 2.14 ± 1.51 μIU/ml and 0.98 ± 0.30 ng/dl, respectively.The correlation between free T4 and TSH levels was positive andstatistically significant according to the Pearson’s correlation coefficient(r = 0.069, p = 0.044). Conclusion: Identifying the normal TSH andfree T4 limits during pregnancy is the first step to safely determine thereal need for thyroid dysfunction treatment. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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