| Autor: |
Yi-Ping Chiu, Yung-Chen Sun, De-Chen Qiu, Yu-Hao Lin, Yin-Quan Chen, Jean-Cheng Kuo, Jie-rong Huang |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-020-15007-3 |
| Popis: |
Galectin-3 consists of an unstructured N-terminal domain (NTD) and a structured carbohydrate-recognition domain and agglutinates neutrophils and glycosylated molecules in the extracellular milieu. Here the authors combine biophysical and biochemical experiments with NMR measurements and show that the galectin-3 NTD undergoes liquid-liquid phase separation (LLPS) and agglutinates other molecules through this process. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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