Sex and race contribute to variation in mitochondrial function and insulin sensitivity

Autor:	Gordon Fisher, Jeannie Tay, Jonathan L. Warren, W. Timothy Garvey, Ceren Yarar‐Fisher, Barbara A. Gower
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	insulin sensitivity mitochondrial function race reactive oxygen species sex Physiology QP1-981
Zdroj:	Physiological Reports, Vol 9, Iss 19, Pp n/a-n/a (2021)
Druh dokumentu:	article
ISSN:	2051-817X
DOI:	10.14814/phy2.15049
Popis:	Abstract Objective Insulin sensitivity is lower in African American (AA) versus Caucasian American (CA). We tested the hypothesis that lower insulin sensitivity in AA could be explained by mitochondrial respiratory rates, coupling efficiency, myofiber composition, or H2O2 emission. A secondary aim was to determine whether sex affected the results. Methods AA and CA men and women, 19–45 years, BMI 17–43 kg m2, were assessed for insulin sensitivity (SIClamp) using a euglycemic clamp at 120 mU/m2/min, muscle mitochondrial function using high‐resolution respirometry, H2O2 emission using amplex red, and % myofiber composition. Results SIClamp was greater in CA (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/81cfc2a201da42cfbe5fad6ea746c9ed Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.