Secondary Narcolepsy as Worsening Sign in a Pediatric Case of Optic Pathway Glioma

Autor: Beatrice Laus, Anna Maria Caroleo, Giovanna Stefania Colafati, Andrea Carai, Romina Moavero, Michela Ada Noris Ferilli, Massimiliano Valeriani, Angela Mastronuzzi, Antonella Cacchione
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Children, Vol 9, Iss 10, p 1455 (2022)
Druh dokumentu: article
ISSN: 2227-9067
DOI: 10.3390/children9101455
Popis: Narcolepsy, a neurologic disorder that leads to excessive daytime sleepiness, may represent a rare consequence of neoplastic lesions involving the sellar/parasellar and hypothalamic regions, the anatomical areas responsible for wakefulness. Optic pathway gliomas represent the most common neoplasm of these regions and present an excellent overall survival, while long-term neurologic impairments, such as visual loss, endocrinopathies, or sleep disorders, are the principal causes of morbidity. In this case report, we describe a non-NF1 patient suffering from a very extensive optical pathway glioma, who several years after the diagnosis in a radiological condition of stable disease, presented with severe narcolepsy, a rare complication, that led to the death of the patient.
Databáze: Directory of Open Access Journals