The Effect of Dexamethasone on Bleomycin-Induced Lung Fibrosis in the Mouse Model of Systemic Sclerosis
| Autor: | Salar PashangZadeh, Marjan Taherian, Fatemeh Vafashoar, Ali Anisian, Kazem Mousavizadeh, Hadi poormoghim, Nazanin Mojtabavi |
|---|---|
| Jazyk: | perština |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, Vol 12, Iss 8, Pp 85-94 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1735-7799 2008-1375 |
| Popis: | Background and Objectives: Systemic sclerosis (SSc) or scleroderma is a chronic connective tissue disease with unknown etiology. This chronic disease is characterized by vascular changes, immune dysfunction, and internal organ fibrosis. Interstitial lung disease (ILD) is a frequent complication and a major cause of mortality in SSc patients. So far, no effective treatment has been identified for this disease. Based on the evidence proposing inflammation as the primary cause of fibrosis in SSc, administration of glucocorticoids has been suggested for the treatment of SSc-ILD. This study was conducted with the aim of investigation of the therapeutic effect of dexamethasone in the mouse model of systemic sclerosis. Methods: In this experimental study, bleomycin was injected subcutaneously into BALB/c mice to induce pulmonary fibrosis. For intervention with dexamethasone, the mice intraperitoneally received 14 doses of the drug. To determine the effectiveness of dexamethasone, histopathological evaluation of lung fibrosis, was performed by Masson's trichrome staining. Results: In this investigation, bleomycin induced severe pulmonary severe lung fibrosis, and injection of dexamethasone significantly decreased collagen deposition and lung fibrosis (p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|