Invasive Pneumococcal Disease Associated with Fanconi-Like Syndrome

Autor: Jade Xiao Jue Soh, Raymond Kai Heng Goh, Shuwei Zheng
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: European Journal of Case Reports in Internal Medicine (2019)
Druh dokumentu: article
ISSN: 2284-2594
DOI: 10.12890/2019_001230
Popis: Acquired causes of Fanconi syndrome in adults are usually due to drugs, toxins or paraproteinaemias. Infectious causes are rarely described. We report a case of invasive pneumococcal disease in a patient who developed a Fanconi-like syndrome during the course of her illness. This patient presented with multiple electrolyte derangements consisting predominantly of hypokalaemia, hypomagnesaemia and hypophosphataemia during hospitalization for invasive pneumococcal disease with possible Austrian syndrome. Further evaluation revealed significant urinary losses of these electrolytes, uric acid and β2-microglobulin. Together with evidence of hypouricaemia, this is suggestive of proximal renal tubulopathy, and hence a Fanconi-like syndrome. The patient’s clinical condition and biochemical anomalies improved following pneumococcus treatment.
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