The Impact of Atmospheric Pollutants on the Prevalence of Atopic Eczema in 6-7-Year-Old Schoolchildren in Spain; ISAAC Phase III

Autor: María Morales Suárez-Varela, Amparo Gallardo-Juan, Luís García-Marcos, Natalia Gimeno-Clemente, Angel López Silvarrey-Varela, Iñaqui Miner-Canflanca, José Batlles-Garrido, Alfredo Blanco-Quiros, Rosa María Busquets-Monge, Begoña Domínguez-Aurrecoechea, Alberto Arnedo-Pena, Carlos González-Díaz, Inés Aguinaga-Ontoso, Antonio Martínez-Gimeno, Agustín Llopis-González
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Iranian Journal of Allergy, Asthma and Immunology, Vol 12, Iss 3 (2013)
Druh dokumentu: article
ISSN: 1735-1502
1735-5249
Popis: Atopic Eczema (AE) is a chronic inflammatory skin disease that affects children and adults, and alters quality of life with a high morbidity rate and severe economic burden. The objective of the present work was to analyse specific atmospheric pollutants (O3, NO, PM10 and SO2) affecting the prevalence of diagnosed AE and its symptoms among 6-7-year-old schoolchildren. The participants included 21311 schoolchildren aged 6-7 years from 8 Spanish regions, whose parents completed the ISAAC Phase III questionnaire to ascertain AE diagnosis and symptoms. The mean levels (µg/m3) of O3, NO, PM10 (particles 10 micrometers or less in diameter) and SO2 were determined in each geographical area participating in this study. According to these mean levels, three levels of exposure to each pollutant were considered: level 1 (percentiles 0-25); level 2 (percentiles 26-74); level 3 (percentiles 75-100). Exposure to O3 was associated with increased prevalence of rashes (exposure level 2, Odds Ratio (OR): 1.22, 95% Confidence Interval (95%CI): 1.02-1.45; level 3 OR: 1.33, 95%CI:1.10-1.61) and diagnosed AE (level 2, OR: 1.27, 95%CI: 1.17-1.39; level 3 OR: 1.27, 95%CI:1.15-1.41). An association was found between the level of NO and a drop in the prevalence of diagnosed AE (exposure level 2, OR: 0.88, 95%CI: 0.81-0.95; level 3 OR: 0.85, 95%CI:0.74-0.97). There was also an association between the highest exposure level to PM10 and a reduced prevalence of rashes (level 3 OR: 0.42, 95%CI: 0.22-0.81) and diagnosed AE (level 3OR: 0.53, 95%CI: 0.38-0.75). Future studies into exposure to O3 and its relationship with allergic diseases may be conducted in order to prevent this association.
Databáze: Directory of Open Access Journals
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