Recovering genotypes and phenotypes using allele-specific genes

Autor: Gamze Gürsoy, Nancy Lu, Sarah Wagner, Mark Gerstein
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Genome Biology, Vol 22, Iss 1, Pp 1-9 (2021)
Druh dokumentu: article
ISSN: 1474-760X
DOI: 10.1186/s13059-021-02477-x
Popis: Abstract With the recent increase in RNA sequencing efforts using large cohorts of individuals, surveying allele-specific gene expression is becoming increasingly frequent. Here, we report that, despite not containing explicit variant information, a list of genes known to be allele-specific in an individual is enough to recover key variants and link the individuals back to their genotypes and phenotypes. This creates a privacy conundrum.
Databáze: Directory of Open Access Journals