Stromal cell-derived factor (SDF)-1α and platelet-rich plasma enhance bone regeneration and angiogenesis simultaneously in situ in rabbit calvaria

Autor: Zhengye Zhang, Yang Zheng, Jianing Zu, Jinpeng Zhuang, Gongping Xu, Jinglong Yan, Xiaoqi Liu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Materials Science: Materials in Medicine, Vol 32, Iss 9, Pp 1-9 (2021)
Druh dokumentu: article
ISSN: 0957-4530
1573-4838
DOI: 10.1007/s10856-021-06600-z
Popis: Abstract The current study aimed to evaluate the effects of chemokine stromal cell-derived factor (SDF)-1α and platelet-rich plasma (PRP) on bone formation and angiogenesis, and to assess whether SDF-1α and PRP could function synergistically. Four evenly distributed defects (8 mm in diameter) were generated in the calvarial bones of New Zealand white rabbits. All rabbits received four treatment regimens containing autogenous bone particles (AB), SDF-1α, or PRP. AB group presented significantly less bone formation compared with the other three groups 2 and 4 weeks after surgery. The amount of newly formed bone in the AB+PRP+SDF-1α group was similar to that in the AB + SDF-1α group at the 4-week time-point (p = 0.65), and was much greater than that in the AB and AB+PRP group (p
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