Exploiting Peptide Self-Assembly for the Development of Minimalistic Viral Mimetics

Autor: Patrizia Janković, Iva Šantek, Ana Sofia Pina, Daniela Kalafatovic
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Frontiers in Chemistry, Vol 9 (2021)
Druh dokumentu: article
ISSN: 2296-2646
DOI: 10.3389/fchem.2021.723473
Popis: Viruses are natural supramolecular nanostructures that form spontaneously by molecular self-assembly of complex biomolecules. Peptide self-assembly is a versatile tool that allows mimicking viruses by creating their simplified versions through the design of functional, supramolecular materials with modularity, tunability, and responsiveness to chemical and physical stimuli. The main challenge in the design and fabrication of peptide materials is related to the precise control between the peptide sequence and its resulting supramolecular morphology. We provide an overview of existing sequence patterns employed for the development of spherical and fibrillar peptide assemblies that can act as viral mimetics, offering the opportunity to tackle the challenges of viral infections.
Databáze: Directory of Open Access Journals