Another string to the polo bow: a new mitotic role of PLK1 in centromere protection

Autor: Tomisin Olukoga, María Fernández-Casañas, Kok-Lung Chan
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Molecular & Cellular Oncology, Vol 6, Iss 6 (2019)
Druh dokumentu: article
ISSN: 2372-3556
23723556
DOI: 10.1080/23723556.2019.1658515
Popis: Polo-like kinase 1 (PLK1) plays a fundamental role in the spatiotemporal control of mitosis. Cells lacking PLK1 activity exhibit characteristic chromosome misalignment due to defects in microtubule-kinetochore organization and attachment. In our recently published paper, we uncover a new role for PLK1 in the preservation and maintenance of centromere integrity.
Databáze: Directory of Open Access Journals
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