Atrial fibrillation is a risk factor for major adverse cardiovascular events in COVID-19

Autor: Michael J. Cutler, Heidi T. May, Tami L. Bair, Brian G. Crandall, Jeffrey S. Osborn, Jared D. Miller, Charles D. Mallender, Joseph B. Muhlestein, Jeffrey L. Anderson, Kirk U. Knowlton, Stacey Knight
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Cardiology: Heart & Vasculature, Vol 43, Iss , Pp 101127- (2022)
Druh dokumentu: article
ISSN: 2352-9067
DOI: 10.1016/j.ijcha.2022.101127
Popis: Background: New-onset atrial fibrillation (AF) during COVID-19 infection is associated with worse cardiovascular outcomes and mortality, with new-onset AF being associated with worse clinical outcomes than recurrent AF. However, it is not known whether a prior history of AF is an independent cardiovascular risk factor predicting worse outcomes in COVID-19 patients. The present investigation sought to determine whether AF should be considered a risk factor for worse outcomes in COVID-19 illness. Methods: From March 2020-September 2021 patients testing positive for SARS-CoV-2 with a prior AF diagnosis (n = 3623) were propensity matched to non-AF SARS-CoV-2 positive patients (n = 3610). Multivariable Cox hazard regression was used to determine subsequent MACE (all-cause death, myocardial infarction, HF and stroke) risk among patients with and without AF. Results: COVID-19 patients with a prior history of AF were more likely to be hospitalized, require ICU care, supplemental oxygen, and ventilator support compared COVID-19 patients without a history of AF. There was a 1.40 times higher rate of MACE in the COVID-19 patients with prior AF compared to patients without prior AF (p
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