Erythropoietin ameliorates genetamicin-induced renal toxicity: A biochemical and histopathological study
| Autor: | Mahmoud Rafieian-Kopaei, Hamid Nasri, Mehdi Nematbakhsh, Azar Baradaran, Alaleh Gheissari, Hamid Rouhi, Seyed Mohammad Ahmadi Soleimani, Milad Baradaran-Ghahfarokhi, Fatemeh Ghaed-Amini, Mohammadreza Ardalan |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Journal of Nephropathology, Vol 1, Iss 2, Pp 109-116 (2012) |
| Druh dokumentu: | article |
| ISSN: | 2251-8363 2251-8819 |
| DOI: | 10.5812/nephropathol.7533 |
| Popis: | Background: Investigations have attempted to modify the outcome of tubular injury by either ameliorating renal tubular damage or promoting tubular regeneration in the case of acute tubular necrosis. Objectives: We investigated the protective effect of Eprex an erythropoietin analogue on tubular injury induced by gentamicin (GM). Materials and Methods: Forty male Wistar rats were randomly divided into four groups. In group 1,rats were served as a sham group. In group 2, rats were injected intraperitoneally with 100 mg/kg of GM for 10 consecutive days (positive control group) and then were sacrificed. In group 3, rats received GM for 10 days then Eprex 100U/kg was injected intraperitoneally for the next 10 days and then they were sacrificed at the day 20th. In group 4 rats were injected a combination of GM (80 mg/kg) and Eprex 100U/kg intraperitoneally for 10 days and then were sacrificed. Results: The results indicated that, Eprex prevented the increase in serum creatinine (Cr) and blood urea nitrogen (BUN). The effect of Eprex on damage score, showed that co-administration of GM and Eprex (group 3 and 4) reduced the kidney tissue damage compared to positive control group (P |
| Databáze: | Directory of Open Access Journals |
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