Reference-free cell type deconvolution of multi-cellular pixel-resolution spatially resolved transcriptomics data

Autor: Brendan F. Miller, Feiyang Huang, Lyla Atta, Arpan Sahoo, Jean Fan
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-30033-z
Popis: Identifying cell-type-specific spatial patterns in ST data is critical for understanding tissue organization but current methods rely on external references. Here the authors develop a reference-free method to effectively recover cell-type transcriptional profiles and proportions.
Databáze: Directory of Open Access Journals