Randomized controlled trial of early endoscopy for upper gastrointestinal bleeding in acute coronary syndrome patients

Autor: Chen-Shuan Chung, Chieh-Chang Chen, Kuan-Chih Chen, Yu-Jen Fang, Wen-Feng Hsu, Yen-Nien Chen, Wei-Chuang Tseng, Cheng-Kuan Lin, Tzong-Hsi Lee, Hsiu-Po Wang, Yen-Wen Wu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-022-09911-5
Popis: Abstract Acute upper gastrointestinal bleeding (UGIB) in acute coronary syndrome (ACS) patients are not uncommon, particularly under dual antiplatelet therapy (DAPT). The efficiency and safety of early endoscopy (EE) for UGIB in these patients needs to be elucidated. This multicenter randomized controlled trial randomized recent ACS patients presenting acute UGIB to non-EE and EE groups. All eligible patients received intravenous proton pump inhibitor therapy. Those in EE group underwent therapeutic endoscopy within 24 h after bleeding. The data regarding efficacy and safety of EE were analyzed. It was early terminated because the UGIB rate was lower than expected and interim analysis was done. In total, 43 patients were randomized to non-EE (21 patients) and EE (22 patients) groups. The failure rate of control hemorrhage (intention-to-treat [ITT] 4.55% vs. 23.81%, p
Databáze: Directory of Open Access Journals
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