Rose (Rosa gallica) Petal Extract Suppress Proliferation, Migration, and Invasion of Human Lung Adenocarcinoma A549 Cells through via the EGFR Signaling Pathway

Autor:	Won-Chul Lim, Hyo-Kyung Choi, Kyung-Tack Kim, Tae-Gyu Lim
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	anticancer invasion migration phytochemicals proliferation rose petal extract Organic chemistry QD241-441
Zdroj:	Molecules, Vol 25, Iss 21, p 5119 (2020)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules25215119
Popis:	We sought to investigate the effect of rose petal extract (RPE) on the proliferation, migration, and invasion of cancer cells. RPE significantly inhibited the growth of lung and colorectal cancer cell lines, with rapid suppression of A549 lung cancer cells at low concentrations. These effects occurred concomitantly with downregulation of the cell proliferation mediators PCNA, cyclin D1, and c-myc. In addition, RPE suppressed the migration and invasion of A549 cells by inhibiting the expression and activity of matrix metalloproteinase-2 and matrix metalloproteinase-9 (MMP-2 and -9). We hypothesize that the suppressive activity of RPE against lung cancer cell proliferation and early metastasis occurs via the EGFR-MAPK and mTOR-Akt signaling pathways. These early results highlight the significant potency of RPE, particularly for lung cancer cells, and warrant further investigation.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/81655441f25d4f4c946b63c9dd8e5649 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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