Characterization of a novel model for atherosclerosis imaging: the apolipoprotein E-deficient rat

Autor:	Jürgen W. A. Sijbesma, Aren van Waarde, Sebastiaan Kristensen, Ilse Kion, Uwe J. F. Tietge, Jan-Luuk Hillebrands, Marian L. C. Bulthuis, Hendrik Buikema, Dalibor Nakladal, Marit Westerterp, Fan Liu, Hendrikus H. Boersma, Rudi A. J. O. Dierckx, Riemer H. J. A. Slart
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Apolipoprotein E-deficient rat Atherosclerosis [18F]2-fluoro-2-deoxy-D-glucose Positron emission tomography (PET) Medical physics. Medical radiology. Nuclear medicine R895-920
Zdroj:	EJNMMI Research, Vol 13, Iss 1, Pp 1-14 (2023)
Druh dokumentu:	article
ISSN:	2191-219X
DOI:	10.1186/s13550-023-01055-5
Popis:	Abstract Background The apolipoprotein E-deficient (apoE −/− ) mouse is a well-established model for studying atherosclerosis. However, its small size limits its use in longitudinal positron emission tomography (PET) imaging studies. Recently, the apoE −/− rat has emerged as an alternative. With this study, we investigate the feasibility of using apoE −/− rats as an in vivo model for longitudinal atherosclerotic PET/CT imaging. Results ApoE −/− rats showed significantly higher [18F]FDG uptake than controls in the aortic arch (+ 18.5%, p
Databáze:	Directory of Open Access Journals
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