Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future

Autor: Nattakarn Suwansaksri, Lukana Preechasuk, Tada Kunavisarut
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: International Journal of Endocrinology, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 1687-8337
1687-8345
DOI: 10.1155/2018/5794054
Popis: Hyperthyroidism is a common endocrine disease. Although thionamide antithyroid drugs are the cornerstone of hyperthyroidism treatment, some patients cannot tolerate this drug class because of its serious side effects including agranulocytosis, hepatotoxicity, and vasculitis. Therefore, nonthionamide antithyroid drugs (NTADs) still have an important role in controlling hyperthyroidism in clinical practice. Furthermore, some situations such as thyroid storm or preoperative preparation require a rapid decrease in thyroid hormone by combination treatment with multiple classes of antithyroid drugs. NTADs include iodine-containing compounds, lithium carbonate, perchlorate, glucocorticoid, and cholestyramine. In this narrative review, we summarize the mechanisms of action, indications, dosages, and side effects of currently used NTADs for the treatment of hyperthyroidism. In addition, we also describe the state-of-the-art in future drugs under development including rituximab, small-molecule ligands (SMLs), and monoclonal antibodies with a thyroid-stimulating hormone receptor (TSHR) antagonist effect.
Databáze: Directory of Open Access Journals
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