| Autor: |
Leonardo I. Goulart, Mário Pedrazolli, Alexandre H. Martori, Alan Eckeli, Heidi H. Sander |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Sleep Science, Vol 7, Iss 1, Pp 62-64 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1984-0063 |
| DOI: |
10.1016/j.slsci.2014.01.001 |
| Popis: |
Introduction: This paper describes narcolepsy with cataplexy in two monozygotic twin sisters. Objective: To clinically illustrate the involvement of neurological, genetic and immunologic systems in narcolepsy. Material and methods: We performed a restropective study of these patients that were followed in the sleep medicine ambulatory clinic of the Faculdade de Medicina de Ribeirao Preto. Results: These sisters are two of the few cases in the literature concordant for narcolepsy with catalepsy and without a “positive HLA” for narcolepsy. They had a typical clinical course of narcolepsy with cataplexy and attended all the neurophysiological diagnostic criteria for narcolepsy. Conclusion: In addition to known possible genetical similarity, this report stresses the role of environmental or unknown genetical factors acting on a specific neuro-imuno-genetical background and resulting in narcolepsy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
