Maternal microbiome disturbance induces deficits in the offspring’s behaviors: a systematic review and meta-analysis
| Autor: | Lucas Hassib, Cilene Lino de Oliveira, Guilherme Araujo Rouvier, Alexandre Kanashiro, Francisco Silveira Guimarães, Frederico Rogério Ferreira |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Gut Microbes, Vol 15, Iss 1 (2023) |
| Druh dokumentu: | article |
| ISSN: | 19490976 1949-0984 1949-0976 |
| DOI: | 10.1080/19490976.2023.2226282 |
| Popis: | ABSTRACTRecent evidence has suggested that changes in maternal gut microbiota in early life may generate neurobiological consequences associated with psychiatric-related abnormalities. However, the number of studies on humans investigating this problem is limited, and preclinical findings sometimes conflict. Therefore, we run a meta-analysis to examine whether maternal microbiota disturbance (MMD) during neurodevelopment might affect the offspring during adulthood. We found thirteen studies, from a set of 459 records selected by strategy registered on PROSPERO (#289224), to target preclinical studies that evaluated the behavioral outcomes of the rodents generated by dams submitted to perinatal enteric microbiota perturbation. The analysis revealed a significant effect size (SMD = −0.51, 95% CI = −0.79 to −0.22, p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|