The impact of age and obesity on outcomes among patients hospitalized with COVID‐19 in Denmark: A nationwide cohort study

Autor: Anton Lund Andersen, Sigrid Bjerge Gribsholt, Lars Pedersen, Reimar Wernich Thomsen, Thomas Lars Benfield, Ole Søgaard, Stig Lønberg Nielsen, Lars Haukali Omland, Birgitte Lindegaard, Bjørn Richelsen, Jacob Bodilsen, Jens Meldgaard Bruun
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Obesity Science & Practice, Vol 9, Iss 4, Pp 355-363 (2023)
Druh dokumentu: article
ISSN: 2055-2238
DOI: 10.1002/osp4.659
Popis: Abstract Purpose Obesity may alter the severity of infection with Coronavirus disease 2019 (COVID‐19). Age may impact the association between body weight and severity of COVID‐19 in patients with obesity. The aim of the study was to examine the association between obesity and severity of infection in a Danish cohort hospitalized with COVID‐19 in the initial wave of the pandemic. Patients and methods Based on data from the nationwide, clinical database: COVID‐DK, risks of intensive care unit (ICU) admission, invasive mechanical ventilation (IMV), and mortality were compared among patients with and without obesity. Interaction with age was examined and we used Inverse Probability of Treatment Weighting regression for confounder adjustment. Results Among 524 patients, 142 (27%) were admitted to the ICU, 112 (21%) required IMV, and 109 (21%) died. Compared to COVID‐19 patients without obesity, patients with obesity displayed a non‐significant increased risk of ICU admission (Relative Risk [RR] 1.19, 95% Confidence Interval [CI] 0.88; 1.60), IMV (RR 1.23, CI 0.86; 1.75) and mortality (RR 1.21, CI 0.84; 1.75). COVID‐19 patients with obesity,
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