| Autor: |
Ambroise D. Ahouidi, Mary A. Rodgers, Abdou Padane, Nafissatou Leye, Ana Olivo, Moustapha Mbow, Aminata Mboup, Papa Alassane Diaw, Aminata Dia, Barbara Harris, Yacine Amet Dia Padane, Gora Lo, Todd V. Meyer, Cyrille K. Diedhiou, Diabou Diagne, Ndeye Coumba Toure Kane, Gavin Cloherty, Souleymane Mboup |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Scientific Reports, Vol 11, Iss 1, Pp 1-4 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-021-02874-z |
| Popis: |
Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that carry mutations in the spike gene are of concern for potential impact to treatment and prevention efforts. To monitor for new SARS-CoV-2 mutations, a panel of specimens were sequenced from both wave one (N = 96), and wave two (N = 117) of the pandemic in Senegal by whole genome next generation sequencing. Amongst these genomes, new combinations of SARS-CoV-2 spike mutations were identified, with E484K + N501T, L452R + N501Y, and L452M + S477N exclusively found in second wave specimens. These sequences are evidence of local diversification over the course of the pandemic and parallel evolution of escape mutations in different lineages. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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