Seroprevalence of SARS-Cov-2 IgG antibodies in patients at a single center in Saudi Arabia

Autor: Waleed H. Mahallawi, Mohammad A. Alsarani, Rami H. Aljohani, Abdulrahman A. Alluhaibi, Turki H. Alamri, Nadir A. Ibrahim, Khalid H. Mahallawi, Omar F. Khabourd
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Annals of Saudi Medicine, Vol 42, Iss 2, Pp 69-74 (2022)
Druh dokumentu: article
ISSN: 0256-4947
0975-4466
DOI: 10.5144/0256-4947.2022.69
Popis: BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has had a massive impact on public health as well as the economy. Understanding the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among undiagnosed individuals is important for developing an informed pandemic response. OBJECTIVE: Investigate the prevalence of undiagnosed COVID-19 disease. DESIGN: Cross-sectional. SETTING: Tertiary care center in Madinah, Saudi Arabia. SUBJECTS AND METHODS: All participants were on follow-up visits to various clinics and had not been previously diagnosed with COVID-19. Enzyme-linked immunosorbent assay was used to specifically assess the anti-spike IgG antibody seropositivity in serum samples. We associated the seropositivity rates of the participants with age, body mass index (BMI), nationality, blood groups, and sex with uni- and multivariate analyses. MAIN OUTCOME MEASURES: Seropositivity for IgG anti-spike antibodies against SARS-CoV-2. SAMPLE SIZE AND CHARACTERISTICS: 527 subjects, with a median (interquartile percentiles) age of the 527 subjects was 34 (24–41). RESULTS: Of the 527 samples, about one-fourth (n=124, 23.5%) were positive for anti-spike IgG antibody against SARS CoV-2. Age was associated with anti-spike IgG antibody positivity (P30 years were more likely to be seropositive (28-29%) than younger participants (15.4%). Additionally, seropositivity was associated with female gender (P30, female gender and BMI >40 were associated with seropositivity. CONCLUSION: The percentage of seropositive individuals reflects the high level of undiagnosed COVID-19 patients among the population. Our results will help in a better evaluation of the public health measures applied during the COVID-19 pandemic and any future public health crises. LIMITATIONS: Sample size was small, single-center study and no rural areas were included. CONFLICT OF INTEREST: None.
Databáze: Directory of Open Access Journals
Externí odkaz: