The human host response to monkeypox infection: a proteomic case series study

Autor: Ziyue Wang, Pinkus Tober‐Lau, Vadim Farztdinov, Oliver Lemke, Torsten Schwecke, Sarah Steinbrecher, Julia Muenzner, Helene Kriedemann, Leif Erik Sander, Johannes Hartl, Michael Mülleder, Markus Ralser, Florian Kurth
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: EMBO Molecular Medicine, Vol 14, Iss 11, Pp n/a-n/a (2022)
Druh dokumentu: article
ISSN: 1757-4684
1757-4676
02157446
DOI: 10.15252/emmm.202216643
Popis: Abstract The rapid rise of monkeypox (MPX) cases outside previously endemic areas prompts for a better understanding of the disease. We studied the plasma proteome of a group of MPX patients with a similar infection history and clinical manifestation typical for the current outbreak. We report that MPX in this case series is associated with a strong plasma proteomic response among nutritional and acute phase response proteins. Moreover, we report a correlation between plasma proteins and disease severity. Contrasting the MPX host response with that of COVID‐19, we find a range of similarities, but also important differences. For instance, CFHR1 is induced in COVID‐19, but suppressed in MPX, reflecting the different roles of the complement system in the two infectious diseases. Of note, the spatial overlap in response proteins suggested that a COVID‐19 biomarker panel assay could be repurposed for MPX. Applying a targeted protein panel assay provided encouraging results and distinguished MPX cases from healthy controls. Hence, our results provide a first proteomic characterization of the MPX human host response and encourage further research on protein‐panel assays in emerging infectious diseases.
Databáze: Directory of Open Access Journals
Externí odkaz: