| Autor: |
Rossaint Rolf, Weis Joachim, Rossaint Jan, Loetscher Philipp D, Hein Marc, Roehl Anna B, Coburn Mark |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
BMC Neurology, Vol 10, Iss 1, p 97 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2377 |
| DOI: |
10.1186/1471-2377-10-97 |
| Popis: |
Abstract Background We investigated the neuroprotective properties of levosimendan, a novel inodilator, in an in vitro model of traumatic brain injury. Methods Organotypic hippocampal brain slices from mouse pups were subjected to a focal mechanical trauma. Slices were treated after the injury with three different concentrations of levosimendan (0.001, 0.01 and 0.1 μM) and compared to vehicle-treated slices. After 72 hrs, the trauma was quantified using propidium iodide to mark the injured cells. Results A significant dose-dependent reduction of both total and secondary tissue injury was observed in cells treated with either 0.01 or 0.1 μM levosimendan compared to vehicle-treated slices. Conclusion Levosimendan represents a promising new pharmacological tool for neuroprotection after brain injury and warrants further investigation in an in vivo model. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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