Seabuckthorn polysaccharides mitigate hepatic steatosis by modulating the Nrf-2/HO-1 pathway and gut microbiota

Autor:	Yan Yan, Haisheng Yuan, Fan Yang, Heiya Na, Xiuling Yu, Jingran Liu, Yuzhen Wang
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Seabuckthorn polysaccharides High-fat diets Nuclear factor erythroid 2-related factor 2 Heme oxygenase-1 Gut microbiota Biotechnology TP248.13-248.65 Microbiology QR1-502
Zdroj:	AMB Express, Vol 14, Iss 1, Pp 1-16 (2024)
Druh dokumentu:	article
ISSN:	2191-0855 49298844
DOI:	10.1186/s13568-024-01756-7
Popis:	Abstract Non-alcoholic fatty liver disease (NAFLD) is becoming a significant global public health threat. Seabuckthorn (Hippophae rhamnoides L.) has been used in traditional Chinese medicine (TCM). The hypolipidemic effects of Seabuckthorn polysaccharides (SP) against high-fat diets (HFD)-induced NAFLD were systematically explored and compared with that of Bifidobacterium lactis V9 (B. Lactis V9). Results showed that HFD-induced alanine transaminase (ALT) and aspartate aminotransferase (AST) levels decreased by 2.8-fold and 4.5-fold, respectively, after SP supplementation. Moreover, the alleviating effect on hepatic lipid accumulation is better than that of B. Lactis V9. The ACC and FASN mRNA levels were significantly reduced by 1.8 fold (P
Databáze:	Directory of Open Access Journals
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