Comparing the Prognostic Value of PTEN and Akt Expression with the Mitotic Activity Index in Adjuvant Chemotherapy-Treated Node-Negative Breast Cancer patients aged

Autor:	Emiel A. M. Janssen, Håvard Søiland, Ivar Skaland, Einar Gudlaugson, Kjell H. Kjellevold, Arne Nysted, Jon-Arne Søreide, Jan P. A. Baak
Jazyk:	angličtina
Rok vydání:	2007
Předmět:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Zdroj:	Cellular Oncology, Vol 29, Iss 1, Pp 25-35 (2007)
Druh dokumentu:	article
ISSN:	1570-5870 1875-8606
DOI:	10.1155/2007/569246
Popis:	Background: The prognostic value of the PI3K/Akt/mTOR pathway and PTEN in invasive breast cancer (IBC) is controversial. Cell proliferation, especially the Mitotic Activity Index (MAI), is strongly prognostic in lymph node-negative (LNneg) invasive breast cancer. However, its prognostic value has not been compared with the value of Akt and PTEN expression. Material and Methods: Prognostic comparison of Her2Neu, p110alpha (PIK3CA), Akt, mTOR, PTEN, MAI and cell-cycle regulators in 125 LNneg patients aged
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c811667cba864472a09db2b8b0d3357c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF