#148 : A Comprehensive Analysis of the Cells Originating from Tripolar Mitosis in the Preimplantation Embryo
| Autor: | Tracey King, Kelli Sorby |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Fertility & Reproduction, Vol 05, Iss 04, Pp 467-467 (2023) |
| Druh dokumentu: | article |
| ISSN: | 26613182 2661-3174 2661-3182 |
| DOI: | 10.1142/S2661318223742431 |
| Popis: | Background and Aims: Tripolar mitosis (TM) is cellular division resulting in three daughter cells instead of the typical identical two. Historically studies have grouped all types of aberrant mitosis together providing insufficient evidence to make clinical decisions. This study examined the fate of tripolar mitosis daughter cells and their impact on embryo development and clinical outcomes. Method: A retrospective analysis of 14,450 embryos cultured in EmbryoScope+ was conducted. Embryos were assessed for cleavage stage TM events; mitosis with two concurrent cleavage furrows. TM embryos were categorised by the mitotic cycle of the TM event; Mitosis 1 (TM1), Mitosis 2 (TM2), Mitosis 3 (TM3) or multiple TM (MTM). TM embryo clinical outcomes were compared to embryos from the same IVF cycles. Timelapse footage was used to assess TM daughter cells outcomes. Results: The incidence of TM embryos (n=448) was 3.1% (TM1 n=118, TM2 n=206, TM3 n=98, MTM n=26). TM1 embryos displayed significantly later pronuclei fade times than control embryos (26.7 vs 25.0 HPI, p |
| Databáze: | Directory of Open Access Journals |
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