| Popis: |
INTRODUCTION: In the nervous system, processes that require high organization, such as neuronal development, adaptation, and plasticity, are controlled by various signaling pathways. Investigating the disruptions in these signaling pathways in schizophrenia aims to reveal the genetic and epigenetic factors of the disease. METHODS: In this study, which we designed as a step towards finding markers in schizophrenia, we evaluated the clinical findings, anthropometric parameters, and NILCO signaling pathway together in schizophrenia. RESULTS: Our results showed that NOTCH and leptin levels in people with schizophrenia were significantly higher than in healthy individuals, and IL-1B was lower than controls. Among the parameters we examined, a positive correlation was found between NOTCH and fat mass, fat percentage, and BMI. Leptin had positive correlations between PANSS positive score, PANSS general, and total PANSS score. DISCUSSION AND CONCLUSION: This study revealed changes in NOTCH, leptin, and IL levels in schizophrenia and that these markers have a significant relationship with each other and clinical parameters. |
