| Autor: |
Xiaoke XING, Shuxian WANG, Juanjuan LI, Qibin SONG, Pingfeng ZHANG |
| Jazyk: |
čínština |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Zhongliu Fangzhi Yanjiu, Vol 51, Iss 7, Pp 594-599 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1000-8578 |
| DOI: |
10.3971/j.issn.1000-8578.2024.24.0082 |
| Popis: |
The ATP-binding cassette (ABC) transporter superfamily comprises membrane proteins that efflux various substrates across extra- and intracellular membranes. Among them, ABCB1, ABCG2, and ABCC1 are directly linked to tumor multidrug resistance (MDR). This review provides an overview of the current understanding on the novel mechanisms and functions of ABCB1, ABCG2, and ABCC1 transporters in tumor MDR, discusses the latest strategies to target these transporters, and explores further opportunities to overcome MDR. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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