Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy

Autor:	Jocelyn Luveta, Ruth M. Parks, David M. Heery, Kwok-Leung Cheung, Simon J. Johnston
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Aromatase inhibitors Breast cancer Endocrine therapy Histology Immunotherapy Invasive lobular carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Oncology and Therapy, Vol 8, Iss 1, Pp 1-11 (2019)
Druh dokumentu:	article
ISSN:	2366-1070 2366-1089
DOI:	10.1007/s40487-019-00105-0
Popis:	Abstract Invasive lobular carcinoma comprises 10–15% of all breast cancers and is increasingly recognised as a distinct and understudied disease compared with the predominant histological subtype, invasive ductal carcinoma. Hallmarks of invasive lobular carcinoma include E-cadherin loss, leading to discohesive morphology with cells proliferating in single-file strands and oestrogen receptor positivity, with favourable response to endocrine therapy. This review summarises the distinct histological and molecular features of invasive lobular carcinoma with focus on diagnostic challenges and the impact on surgical management and medical therapy. Emphasis is placed on recent advances in our understanding of the unique molecular biology of lobular breast cancer and how this is optimising our therapy approach in the clinic.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/e810488bf9264f77af6e8949c4a287ac Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ