Serum sclerostin in vascular calcification in CKD: a meta-analysis

Autor:	Yan Lin, Liman Mao, Siqi Chen, Canxin Zhou
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Cardiovascular events chronic kidney disease sclerostin serum sclerostin vascular calcification Diseases of the genitourinary system. Urology RC870-923
Zdroj:	Renal Failure, Vol 45, Iss 1 (2023)
Druh dokumentu:	article
ISSN:	0886022X 1525-6049 0886-022X
DOI:	10.1080/0886022X.2023.2186151
Popis:	AbstractVascular calcification (VC) is recognized as a predictor of all-cause and CVD mortality in chronic kidney disease (CKD). VC in CKD is possibly associated with serum sclerostin. The study systematically investigated the role of serum sclerostin in VC in CKD. Following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols, a systematic search was performed of the PubMed, Cochrane Library, and EMBASE databases from inception to 11 November 2022, to identify relevant eligible studies. The data were retrieved, analyzed, and summarized. The hazard ratios (HRs) and odds ratios (ORs) with their corresponding confidence intervals (CIs) were derived and pooled. Thirteen reports (3125 patients) met the inclusion criteria and were included. Sclerostin was associated with the presence of VC (pooled OR = 2.75, 95%CI = 1.81–4.19, p
Databáze:	Directory of Open Access Journals
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