| Autor: |
Roseane P. Medeiros, Norah A. Terrault, Daniel F. Mazo, Claudia P. Oliveira, Jennifer Dodge, Patricia M. Zitelli, Marta H. Lopes, Flair J. Carrilho, Mário G. Pessoa |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Annals of Hepatology, Vol 28, Iss 2, Pp 100891- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1665-2681 |
| DOI: |
10.1016/j.aohep.2022.100891 |
| Popis: |
Introduction and Objectives: Some studies suggest chronic HCV infection diminishes responses to the anti-HBV vaccine. We evaluated the efficacy of double versus standard dose HBV vaccination among HCV patients without cirrhosis. Patients and Methods: 141 adults with untreated chronic HCV were randomized to HBV vaccination with double dose (40μg) or standard dose (20μg) at 0, 1 and 6 months; 70 healthy HCV-negative patients given standard dose served as controls. Vaccine response was defined by anti-HBs ≥10 mIU/mL. Results: 128 patients (60 double, 68 standard doses) completed the study. Patients were of median age 52 years, 61% female, 60% fibrosis |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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