Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti

Autor: Jasmine B. Ayers, Heather G. Coatsworth, Seokyoung Kang, Rhoel R. Dinglasan, Lei Zhou
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-020-01614-9
Popis: Ayers et al. report rapid induction of apoptosis in the midgut of Aedes aegypti mosquitoes within 2 hours of infection by dengue and Zika viruses, and find that inhibiting apoptosis led to increased virus proliferation in the midgut. These results suggest rapid induction of apoptosis as an innate immune mechanism mediating midgut infection in this mosquito vector.
Databáze: Directory of Open Access Journals
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