| Autor: |
Rui eLi, Ayman eRezk, Luke eHealy, Gillian eMuirhead, Alexandre ePrat, Jennifer L Gommerman, Amit eBar-Or |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Frontiers in Immunology, Vol 6 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2015.00626 |
| Popis: |
Important antibody-independent pathogenic roles of B cells are emerging in autoimmune diseases including multiple sclerosis (MS). The contrasting results of different treatments targeting B cells in patients (in spite of predictions of therapeutic benefits from animal models) call for a better understanding of the multiple roles that distinct human B cell responses likely play in MS. In recent years, both murine and human B cells have been identified with distinct functional properties related to their expression of particular cytokines. These have included regulatory (Breg) B cells (secreting IL-10 or IL-35), and pro-inflammatory B cells (secreting TNFɑ, LT, IL-6 and GM-CSF). Better understanding of human cytokine-defined B cell responses is necessary in both health and diseases such as MS. Investigation of their surface phenotype, distinct functions and the mechanisms of regulation (both cell-intrinsic and -extrinsic) may help develop effective treatments that are more selective and safe. In this review, we focus on mechanisms by which cytokine-defined B cells contribute to the peripheral immune cascades that are thought to underlie MS relapses, and the impact of B cell-directed therapies on these mechanisms. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
